ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING
摘要：
Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.
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关键词：
Animals Humans Alzheimer Disease Glycosylation End Products, Advanced Diabetes Mellitus Reactive Oxygen Species Extracellular Matrix Proteins Receptors, Immunologic Cell Aging Aged
DOI：
10.1086/381243
被引量：
年份：
1995
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