Human Smad3 and Smad4 are sequence-specific transcription activators.
摘要：
Mounting evidence indicates that Smad are required for TGF beta , but the way(s) in which Smad propagate this signal is unclear. We found that two Smad (and ) could specifically recognize an identical 8 bp palindromic sequences (GTCTAGAC). Tandem repeats of this palindrome conferred striking TGF beta responsiveness to a minimal promoter. This responsiveness was abrogated by targeted deletion of the cellular gene. These results define a novel biochemical property of Smad that is likely to play a direct role in the biologic responses to TGF beta and related ligands.
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关键词：
Humans Transforming Growth Factor beta DNA-Binding Proteins Trans-Activators Signal Transduction Consensus Sequence Protein Structure, Tertiary Protein Binding Genes, Tumor Suppressor Smad3 Protein
DOI：
10.1016/S1097-2765(00)80061-1
被引量：
年份：
1998
Elsevier
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