Estrogen and progestin binding by cytosolic and nuclear fractions of human meningiomas.
摘要：
Frozen tissue samples were obtained from in 42 patients. Both cytosolic and nuclear fractions were tested for and using equilibrium assays. The results were correlated with the age of the patient and the histological type and cellular density of the . Cytosolic was noted in 25 (60%) of 42 tumors, with eight (19%) of the 42 having levels over 10 femtomoles (fM)/mg protein. Nuclear was detected in 16 (57%) of 28 tumors, with six (21%) of the 28 having levels over 10 fM/mg protein. Cytosolic was noted in 16 (73%) of 22 samples, with levels in nine (41%) of 22 being greater than 10 fM/mg protein. There was no correlation between the level of cytoplasmic and either the level of cytoplasmic or the level of nuclear . In several specimens, level of cytoplasmic in excess of 100 fM/mg protein were found in tissues demonstrating little or no by either the or the . This discrepancy differs from the situation found in other hormonally responsive tissues such as breast or uterus, and suggests either a possible derangement of the normal cellular hormonal control mechanism or that the measured hormone binder is a molecule other than a classical hormone receptor.
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关键词：
Humans Cytosol Cell Nucleus Meningeal Neoplasms Estradiol Progesterone Receptors, Estradiol Receptors, Progesterone Estrogens Adult
DOI：
10.3171/jns.1985.62.5.0750
被引量：
年份：
1985
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