Neurotrophin signaling through the p75 neurotrophin receptor.

First, p75NTR is a Trk co-receptor that can enhance or suppress neurotrophin-mediated Trk receptor activity. Second, p75NTR autonomously activates signaling...

PP Roux，PA Barker - 《Progress in Neurobiology》

Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures.

Activity is known to regulate the expression of the neurotrophin brain-derived neurotrophic factor (BDNF), and BDNF has been shown to influence the ...

LC Rutherford，A Dewan，HM Lauer，... - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》

Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

BACKGROUND: Exposure to anesthetics during synaptogenesis results in apoptosis and subsequent cognitive dysfunction in adulthood. Probrain-derived neurotro...

BP Head，HH Patel，IR Niesman，... - 《Anesthesiology》

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise

In this study we examined the timecourse of induction of brain-derived neurotrophic factor (BDNF) mRNA and protein after 1, 3, 5, 7, 14 and 28 days of exer...

Paul A. Adlard and Victoria M. Perreau and Christie Engesser-Cesar and Carl W. Cotman - 《Neuroscience Letters》

Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity

Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally related proteins that promote neuronal differentiation and su...

KK Cowansage，JE Ledoux，MH Monfils - 《Current Molecular Pharmacology》

Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions

Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotroph...

Blum，R. - 《Physiology》

Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: a role for the transcription factor NFA...

A member of the neurotrophin family, brain-derived neurotrophic factor (BDNF) regulates neuronal survival and differentiation during development. Within th...

RD Groth，PG Mermelstein - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》

Differential Susceptibility to Neurotoxicity Mediated by Neurotrophins and Neuronal Nitric Oxide Synthase

Primary neuronal cultures from mice lacking nNOS grown on a glial feeder layer fail to respond to neurotrophin-mediated enhancement of neurotoxicity. Together...

AF Samdani，C Newcamp，A Resink，... - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》

Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation

Epigenetic regulation of histones mediates neurotrophin actions with histone acetylation enhancing cAMP response element-binding (CREB)-associated transcri...

N Sen，SH Snyder - 《Proceedings of the National Academy of Sciences of the United States of America》