The role of M cells in the protection of mucosal membranes
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30
摘要：
The mucosa-associated lymphoid tissues continuously take up antigenic matter from the lumen to generate immune responsesor to maintain immune tolerance. This antigen sampling is performed by highly specialised epithelial cells, the membranous(M) cells of the dome epithelia. M cells possess a unique ultrastructure and lie in close contact to lymphoid cells. Theyendocytose soluble and solid substances, including entire microorganisms, at their apical membrane, transport these in vesiclesto their basolateral membrane and exocytose them to the intercellular space. This review summarises the structural and functionalpeculiarities of M cells in different species and at the different sites of lymphoid tissue along the digestive and respiratorytracts. Specialisations of M cells for antigen uptake and transport comprise the composition of their apical membrane andits glycocalyx, a modified cytoskeleton as compared to enteroc
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DOI：
10.1007/s004180050186
被引量：
年份：
1997
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