Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.
摘要：
Invasion of antigens through the mucosal surface can be prevented by the common mucosal immune system, including Peyer's patches (PPs) and nasopharyngeal-associated lymphoreticular tissue (NALT). The adenoids (nasopharyngeal tonsils) comprise one of the NALTs and constitute the major part of Waldeyer's lymphoid ring in . However, the role of the lymphoepithelium, including M and dendritic (DCs), in the adenoids is unknown compared with the epithelium of PPs. NALTs also have unique functions such as the barrier of epithelial and of antigens by M and DCs, and may play a crucial role in airway . The lymphoepithelium of adenoids has well-developed tight junctions that play an important role in the barrier function, the same as nasal epithelium but not palatine tonsillar epithelium. Tight junction molecules are expressed in both M and DCs as well as epithelial , and various antigens may be sampled, transported, and released to lymphocytes through the while they maintain the integrity of the epithelial barrier. This review summarizes the recent progress in our understanding of how M and DCs control the epithelial barrier in the adenoids.
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DOI：
10.3109/00016489.2010.520022
被引量：
年份：
2011
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