Threo-DOPS controlled release formulation
申请(专利)号：
11/698974
申请日期：
01/29/2007
公开/公告号：
US8158149
公开/公告日期：
04/17/2012
申请(专利权)人：
Chelsea Therapeutics, Inc. (Charlotte, NC, US)
被引量：
摘要：
The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.
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