Therapeutic system for administering clonidine transdermally
Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm. sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elici...
SK Chandrasekaran，S Darda，AS Michaels，... - US
Mineral oil polyisobutylene, colloidal silicon dioxide mixture; controlled release
Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery syste...
DJ Enscore，RM Gale - US
MATRIX COMPOSITION FOR TRANSDERMAL THERAPEUTIC SYSTEM
Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble ...
DAVID J. ENSCORE，ROBERT M. GALE - CA
TRANSDERMAL MULTIPOLYMER DRUG DELIVERY SYSTEM
a composition for dermal application includes a product, a multipolym u00e8re of vinyl acetate, polyethylene and may have one or more monomers, a natural or synthetic rubber and adhesive agent. the relationship between the multipolym u00...
SABLOTSKY Steven，QUESTEL John M. - US
Transdermal acrylic multipolymer drug delivery system
A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber ...
S Steven，Gentile Joseph A. - WO
METHOD AND DEVICE FOR THE RELEASE OF DRUGS TO THE SKIN
A method enhancing the adhesion of a molded pressure sensitive adhesive, comprising adding to the adhesive, prior to assembly, a certain amount of clay strengthening adhesion and release power of the drug substance. dermal composition co...
SABLOTSKY Steven，GENTILE Joseph A. - WO
Matrix composition for transdermal therapeutic system
Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble ...
DJ Enscore，RM Gale - US
Transdermal acrylic multipolymer drug delivery system
of EP0379045 A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer t...
SABLOTSKY STEVEN，GENTILE JOSEPH A - CA
METHOD AND DEVICE FOR THE RELEASE OF DRUGS TO THE SKIN
A method of increasing the adhesiveness of a shaped pressure sensitive adhesive, comprising adding an adhesiveness and drug release increasing amount of a clay to said adhesive prior to casting of the adhesive.
JA Gentile
Polyisobutylene adhesives for transdermal devices
An in-line adhesive, useful for transdermal delivery devices comprising a mixture of high and low molecular weighted polyisobutylene having a ratio HMW PIB:LMW PIB in the range of about 5-40:95-60 which is substantially free of plasticiz...
KS Wang，JL Osborne，JA Hunt，...
