Synthesis of coumarins by ring-closing metathesis using Grubbs' catalyst
摘要：
A novel generally applicable synthesis of coumarins from phenolic substrates utilizing ring-closing metathesis is described. This sequence involves O-allylation of phenols followed by ortho-Claisen rearrangement, subsequent based-induced isomerization affording 2-(1-propenyl)phenols, acylation with acryloyl chloride, and finally ring-closing metathesis (RCM) with Grubbs' second generation catalyst.
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DOI：
10.1016/S0040-4039(03)00902-X
被引量：
年份：
2003
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来源期刊
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2006
被引量：16
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