Cell growth inhibition by antitumor prostaglandin and its modulation by MRP/GS-X pump.
摘要：
Regulation of cell growth and proliferation is of fundamental biological interest. Accumulating evidence suggests that arachidonic acid and its metabolites constitute a novel class of intracellular second messengers. The A and J series of prostaglandin (PG; i. e., PGA and PGJ) suppress proliferation of tumor cells in vitro as well as in vivo without affecting intracellular cAMP levels 1 . These antitumor PGs are actively transported into tumor cells 2 and their nuclear accumulation correlates closely with the inhibition of cell growth 3 and the arrest of cell cycle in the G 1 phase 4 . The significance of the antitumor PGs as novel biochemical probes is being strengthened by a newly developed method called "three-component coupling synthesis", which has made it possible to generate large quantities of structurally modified PGs 5,6 . In this study, we used this method to synthesize Δ 7 -PGA 1 methyl ester as a new biochemical probe to study the molecular mechanism in cell growth inhibition by antitumor PGs.
展开
DOI：
10.1007/978-1-4899-1813-0_58
被引量：
年份：
1997
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
