One-Step Construction of Atropisomers Bearing 1,5-Central and Axial Chirality via Catalytic Diastereo- and Atroposelective Remote Desymmetrizing Alkynylation

Catalytic asymmetric construction of atropisomers with multiple stereogenic elements has recently become an emerging area. However, general methods that pr...

S Wang，L Li，M Jiang，... - 《Acs Catalysis》

Phosphine-Catalyzed Stereospecific and Enantioselective Desymmetrizative [3+2] Cycloaddition of MBH Carbonates and N-(2-tert-Butylphenyl)maleimides

Herein, we report an l-valine-derived amide phosphine-catalyzed [3+2] cyclization of MBH carbonates and N-(2-tert-butylphenyl)maleimides via asymmetric desymmetrization. Bicyclic N-aryl succinimide derivatives bearing three continuous ch...

J Hou，W Hao，Y Chen，... - 《Journal of Organic Chemistry》

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

Atropisomeric biaryls carrying ortho-hydroxymethyl and formyl groups were made enantioselectively by desymmetrisation of dialdehyde or diol substrates. The...

S Staniland，Y Bo，Nelson Giménez-Agulló，... - Wiley-Blackwell Online Open

Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases

Atropisomeric ligands have found numerous powerful applications in catalysis, and the atropisomeric biaryl bisphos-phine binap played an important role in ...

PCPW Bo - 《Angewandte Chemie》

Synthesis and Resolution of 2,2′‐Bis‐diphenylphosphino(3,3′)biindolyl: A New Atropisomeric Ligand for Transition Metal Catalysis.

ChemInformBerens, Ulrich, et al., " Synthesis and Resolution of 2,2'-bis-diphenylphosphino[3,3']biindolyl; a New Atropisomeric Ligand for Transition ...

U Berens，JM Brown，J Long，... - 《Cheminform》

Atropisomeric Diaryl Ethers and other Non-Biaryl Atropisomers

Atropisomerism is a property exhibited by molecules where rotation about one or more bonds is restricted. Along with biaryls, which are widely utilised in ...

Page，Abigail

New Class of Chiral Allenic Ligands in Asymmetric Catalysis

The central issue of the asymmetric synthesis is the development of chiral ligands which are often adopted several chirality elements, sush as stereogenic centers and atropisomeric structures. Inspired by the unique configurations of all...

X Pu - American Chemical Society Southwest Regional Meeting

Synthesis and resolution of 2,2'-bis-diphenylphosphino [3,3']biindolyl ; a new atropisomeric ligand for transition metal catalysis

A synthesis of the title ligand is described in which the key step is the dilithiation of 1,1'-bis(dimethylaminomethyl)-3,3'-biindolyl and electrophilic trapping with ClPPh2. Concomitant N-deprotection and resolution with bis[(R)-dimethy...

Ulrich，Berens，and，... - 《Tetrahedron Asymmetry》

Synthesis and resolution of 2,2'-bis-diphenylphosphino [3,3']biindolyl ; a new atropisomeric ligand for transition metal catalysis

A synthesis of the title ligand is described in which the key step is the dilithiation of 1,1'- ja:math (dimethylaminomethyl)-3,3'-biindolyl and electroph...

Ulrich Berens a b，John M. Brown a，James Long a，... - 《Tetrahedron Asymmetry》

PROCESS FOR THE PREPARATION OF ATROPISOMERIC ANALOGUES OF 4-AMINOPYRIDINE

The present invention relates to a process for the preparation of 3,4-disubstituted pyridines from commercially available starting materials. In particular, the invention relates to the process for the preparation for a compound of formu...

AC Spivey，SG Davey，F Zhu - WO