MAP Kinases in Immune Responses

MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essentialroles in both innate and adaptive immune resp...

YL Zhang，C Dong - 《中国免疫学杂志(英文版)》

MAP KINASES IN THE IMMUNE RESPONSE.

Explores the function and regulation of MAP kinases in different components or phases of immune responses. MAP kinases in innate immune responses; Regulati...

Dong，Chen，Davis，... - 《Annual Review of Immunology》

Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.

Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recog...

K Honda，A Takaoka，T Taniguchi - 《Immunity》

Phagocytosis and clearance of apoptotic cells is mediated by MER.

Examines the role of Mer receptor tyrosine kinase for the engulfment and clearance of apoptotic cells. Association of apoptotic cells clearance with the nu...

Scott，Rona，S.，... - 《Nature》

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE). The increased bioavailability...

J Banchereau，V Pascual - 《Immunity》

CD14 is required for MyD88-independent LPS signaling

The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea-mutated mice that showed defective responses to microbial in...

Z Jiang，P Georgel，X Du，... - 《Nature Immunology》

Circuitry of nuclear factor kappaB signaling.

Immunol Rev. 2006 Apr;210:171-86. Review

A Hoffmann - 《Immunological Reviews》

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

The innate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammatory disease. This control is mediated, in part, b...

M Gilchrist，V Thorsson，B Li，... - 《Nature》

Type I Interferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

The innate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammatory disease. This control is mediated, in part, b...

Kenya，Honda，and，... - 《Immunity》

Circuitry of nuclear factor κB signaling

Summary: Over the past few years, the transcription factor nuclear factor (NF)‐κB and the proteins that regulate it have emerged as a signaling system of pre‐eminent importance in human physiology and in an increasing number of pathol...

A Hoffmann，D Baltimore - 《Immunological Reviews》