MAP Kinases in Immune Responses

MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essentialroles in both innate and adaptive immune resp...

YL Zhang，C Dong - 《中国免疫学杂志(英文版)》

MAP kinases in immune responses.

MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune res...

YL Zhang，C Dong - IEEE Xplore

TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response

Summary The activation of Toll-like receptors (TLRs) in dendritic cells (DCs) triggers a rapid inflammatory response to pathogens. However, this response m...

Carla V. Rothlin and Sourav Ghosh and Elina I. Zuniga and Michael B.A. Oldstone and Greg Lemke - 《Cell》

Notch Signaling in Cancer

Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or pro...

EJ Allenspach，I Maillard，JC Aster，... - 《Cancer Biology & Therapy》

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

Engagement of Toll-like receptors (TLRs) on macrophages leads to activation of the mitogen-activated protein kinases (MAPKs), which contribute to innate im...

H Chi，SP Barry，RJ Roth，... - 《Proc Natl Acad Sci U S A》

Aging of the Innate Immune System

The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate...

AC Shaw，S Joshi，H Greenwood，... - 《Current Opinion in Immunology》

Map kinase signaling pathways and hematologic malignancies

Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major gr...

LC Platanias - 《Blood》

Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation

There is increasing awareness that helminth infections can ameliorate proinflammatory conditions. In part, this is due to their inherent ability to induce ...

CM Kane，L Cervi，J Sun，... - 《Journal of Immunology》

Cell Signaling and the Genesis of Neuropathic Pain

Damage to the nervous system can cause neuropathic pain, which is in general poorly treated and involves mechanisms that are incompletely known. Currently ...

RR Ji，G Strichartz - 《Sci Stke》

Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells

Interleukin (IL)-7 is essential for normal T cell development. Previously, we have shown that IL-7 increases viability and proliferation of T cell acute ly...

Barata，T J. - 《Journal of Experimental Medicine》