Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells

The beta-galactosidase reporter gene, either free or complexed with various cationic vectors, was microinjected into mammalian cells. Cationic lipids but n...

Pollard，H. - 《Journal of Biological Chemistry》

Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates

Alexa 350, Alexa 430, Alexa 488, Alexa 532, Alexa 546, Alexa 568, and Alexa 594 dyes are a new series of fluorescent dyes with emission/excitation spectra ...

N Panchuk-Voloshina，RP Haugland，J Bishop-Stewart，... - 《Journal of Histochemistry & Cytochemistry Official Journal of the Histochemistry Society》

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids.

The mechanism whereby cationic lipids destabilize cell membranes to facilitate the intracellular delivery of macromolecules such as plasmid DNA or antisens...

Hafez，I，M，... - 《Gene Therapy》

Tailoring nanocarriers for intracellular protein delivery

Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering activ...

G Zhen，A Biswas，M Zhao，... - 《Cheminform》

Tailoring nanocarriers for intracellular protein delivery

Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering activ...

Z.，Biswas，A.，... - 《Chemical Society Reviews》

Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical ...

Carboxyl groups of bovine RNase A were amidated with ethylenediamine (to convert negative charges of carboxylate anions to positive ones), 2-aminoethanol (...

 - 《Biochemistry》

Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization

In the post-genomic era, there is pressing need for development of protein manipulation methodology to analyze functions of proteins in living cells. For t...

J Futami，M Kitazoe，T Maeda，... - 《Journal of Bioscience & Bioengineering》

Polyethylenimine In Medicinal Chemistry

Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vi...

Paola Vicennati, Antonella Giuliano, Giancarlo Ortaggi, Andrea Masotti - 《Current Medicinal Chemistry》

Polyethylenimine in medicinal chemistry.

Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vi...

Paola，Vicennati，Antonella，... - 《Current Medicinal Chemistry》

Grosse, S, Th??venot, G, Monsigny, M and Fajac, I. Which mechanism for nuclear import of plasmid DNA complexed with polyethylenimine derivatives? J Gene Med 8: 845-851

To investigate the nuclear import mechanism of plasmid/polyethylenimine (PEI) derivative complexes and the putative nuclear targeting of therapeutic genes by the use of oligosaccharides, we have studied the nuclear import of plasmid DNA ...

S Grosse，G Thévenot，M Monsigny，... - 《Journal of Gene Medicine》