Antibodies to interleukin 12 abrogate established experimental colitis in mice.

In this study, we describe a novel murine model of chronic intestinal inflammation induced by the hapten reagent 2,4,6-trinitrobenzene sulfonic acid (TNBS)...

MF Neurath，I Fuss，BL Kelsall，... - 《Journal of Experimental Medicine》

Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by acti...

Szabo，J S. - 《Science》

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immu...

S Hue，P Ahern，S Buonocore，... - 《Journal of Experimental Medicine》

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

The regulatory T (Treg) cells restrain immune responses through suppressor-function elaboration that is dependent upon expression of the transcription fact...

YP Rubtsov，JP Rasmussen，EY Chi，... - 《Immunity》

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

The naturally occurring regulatory T cell (T(r)) is the pivotal cell type that maintains self-tolerance and exerts active immune suppression. The developme...

Wan,YY，Flavell,RA - 《Nature》

Distinct Effects of T-bet in T[sub H]1 Lineage Commitment and IFN- Production in CD4 and....

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T[sub H]) lymphocytes in part by activating the hallmark T[sub H]1 cytokine, interferon-γ (IFN-γ). IFN-γ is al...

Szabo，Susanne，J.，... - 《Science》

Distinct Effects of T-bet in T[sub H]1 Lineage Commitment and IFN-ϒ Production in CD4 and....

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T[sub H]) lymphocytes in part b...

Szabo，Susanne，J.，... - 《Science》

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T[sub H]) lymphocytes in part b...

Rubtsov，P Y.，Rasmussen，... - IMMUNITY -CAMBRIDGE MA-

Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.

BACKGROUND: Probiotic bacteria exhibit a variety of properties, including immunomodulatory activity, which are unique to a particular strain. Thus, not all...

 - 《American Journal of Gastroenterology》

Autoimmune-Mediated Intestinal Inflammation–Impact and Regulation of Antigen-Specific CD8 + T Cells

Background & Aims: Few data exist regarding mechanisms of mucosal CD8 + T-cell reactivity to epithelial-specific antigen. To dissect the immunologic mechan...

AM Westendorf，D Fleissner，S Deppenmeier，... - 《Gastroenterology》