The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.

Gamma-hydroxybutyrate penetrates freely into the brain when administered intravenously or intraperitoneally. This is a unique situation for a molecule with signalling properties in the brain. Thus, the γ-hydroxybutyrate concentration in...

B Loi - 《Progress in Neurobiology》

Childhood absence epilepsy: genes, channels, neurons and networks.

Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a multifactorial genetic aetiology. Molecular-genetic analyses of aff...

V Crunelli，N Leresche - 《Nature Reiview Neuroscience》

THE γ-HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS

γ-Hydroxybutyrate is a metabolite of GABA which is synthesized and accumulated by neurons in brain. This substance is present in micromolar quantities in ...

MICHEL，MAITRE - 《Progress in Neurobiology》

THE y-HYDROXYBUTYRATE SIGNALING SYSTEM IN BRAIN : ORGANIZATION AND FUNCTIONAL IMPLICATIONS

gamma-Hydroxybutyrate is a metabolite of GABA which is synthesized and accumulated by neurons in brain. This substance is present in micromolar quantities in all brain regions investigated as well as in several peripheral organs. Neurona...

MICHEL MAITRE

Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system

Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal r...

HG Cruz，T Ivanova，ML Lunn，... - 《Nature Neuroscience》

THE -HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS - I. Regional concentration in developing rat, monkey and human brain

the gamma-hydroxybutyrate signalling system in brain: organization and functional implications - i. regional concentration in developing rat, monkey and human brain

Michel Maitre - 《Progress in Neurobiology》

Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system.

The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic dopamine system, which is inhibited by putative anti-craving compounds. ...

G Hans，Cruz，Tatiana，... - 《Nature Neuroscience》

Protein-Protein Interactions in the Tetraspanin Web

Tetraspanins are evolutionarily conserved membrane proteins that tend to associate laterally with one another and to cluster dynamically with numerous part...

S Levy，T Shoham - 《Physiology》

Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.

The aim of this study was to investigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave (SW) sleep in normal ...

EV Cauter，L Plat，MB Scharf，... - 《Journal of Clinical Investigation》

Cellular Mechanisms of the Slow (

The slow (2+ current and a Ca²⁺-activated, nonselective cation current. These results suggest an active role for the thalamus in shaping t...

Hughes，Stuart，W.，... - 《Neuron》