The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.

Gamma-hydroxybutyrate penetrates freely into the brain when administered intravenously or intraperitoneally. This is a unique situation for a molecule with signalling properties in the brain. Thus, the γ-hydroxybutyrate concentration in...

B Loi - 《Progress in Neurobiology》

Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in thecat

Much experimental and clinical data suggest that the pharmacological profile of modafinil, a newly discovered waking substance, differs from those of amphe...

JS Lin，Y Hou，M Jouvet - 《Proceedings of the National Academy of Sciences of the United States of America》

A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system.

The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABAA and GABAB receptors. GABAB receptors differ ...

U Misgeld，M Bijak，W Jarolimek - 《Progress in Neurobiology》

Vigilance and Automobile Accidents in Patients With Sleep Apnea or Narcolepsy

Patients with obstructive sleep apnea or narcolepsy report difficulty remaining alert and attentive. To detect impaired vigilance, we designed Steer Clear,...

L Findley，M Unverzagt，R Guchu，... - 《Chest》

A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system

The inhibitory neurotransmitter GABA acts in the mammalian brain through two different receptor classes: GABAA and GABAB receptors. GABAB receptors differ ...

BW Jarolimek - 《Progress in Neurobiology》

Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat

Seventeen adult cats were chronically implanted with electrodes for polygraphic recordings in order to assess the role of catecholamines in the arousal eff...

JS Lin，Bernard Roussel，Hideo Akaoka，... - 《Brain Research》

Gamma-Hydroxybutyric Acid in the Treatment of Alcohol Dependence: A Double-Blind Study

The effect of gamma-hydroxybutyric acid on alcohol consumption and alcohol craving in alcoholics was investigated in a randomized double-blind study versus...

Luigi，Gallimberti，Mila，... - 《Alcoholism Clinical & Experimental Research》

Differential diagnosis in hypersomnia

Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicin...

T Hallböök

Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings.

Previous studies on the effects of gamma-hydroxybutyrate (GHB) on the sleep and clinical response of patients with narcolepsy are reviewed. New information...

Mamelak Mortimer，Scharf Martin B.，Woods Marcia - 《Sleep》

Gamma-hydroxybutyric acid for treatment of opiate withdrawal syndrome.

In a double-blind placebo-controlled trial, gamma-hydroxybutyric acid (GHB) (25 mg/kg orally) suppressed most of the withdrawal symptomatology in 14 heroin...

L Gallimberti，M Cibin，P Pagnin，... - 《Neuropsychopharmacology》