Lipoprotein(a) and the atherothrombotic process: Mechanistic insights and clinical implications

Although many epidemiologic studies have pointed at an association between plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular risk, the data obtain...

AM Scanu - 《Current Atherosclerosis Reports》

The influence of bicarbonate administration on blood pH in a "closed system": Clinical implications

An in vitro comparison was made of the effect of isotonic and hypertonic NaHCO 3 solutions on blood pH when the elimination of carbon dioxide was prevented. The results demonstrate that the rise in P co 2 which occurs after addition of i...

EM Ostrea，GB Odell - 《Journal of Pediatrics》

Enantiomeric Determination of the Phenylmorpholinol Metabolite of Bupropion in Human Plasma Using Coupled Achiral–Chiral Liquid Chromatography

A coupled achiral–chiral stationary phase liquid chromatographic technique was developed to separate and quantitate the enantiomers of the phenylmorpholin...

RF Suckow，F Zhangming，TB Cooper - 《Biomedical Chromatography》

The challenge of achieving target drug concentrations in clinical trials: experience from the Symphony study.

The Symphony study compared four immunosuppressant regimens, defined by protocol-specified target drug concentrations. This subanalysis examines actual dru...

H Ekberg，RD Mamelok，TC Pearson，... - 《Transplantation》

Evaluation on the role of sulfuric acid in the mechanisms of new particle formation for Beijing case

New particle formation (NPF) is considered as an important mechanism for gas-to-particle transformation, and gaseous sulfuric acid is believed as a crucial...

ZB Wang，M Hu，DL Yue，... - 《Atmospheric Chemistry & Physics》

Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/ myofibril system in muscle

After discussing approaches to the modelling of mitochondrial regulation in muscle, we describe a model that takes account, in a simplified way, of some as...

GJ Kemp，DN Manners，JF Clark，... - 《Molecular & Cellular Biochemistry》

The Neuroendocrine Regulation and Implications of Pulsatile GH Secretion

Gender differences are evident in many endocrine pathophysiologies. Like other neuroendocrine axes, regulation of the growth hormone (GH) axis is subject t...

Veldhuis，D Johannes - 《Endocrinologist》

The influence of polyhydroxylated compounds on a hydrated phospholipid bilayer: a molecular dynamics study

Molecular dynamics simulations are used to investigate the interaction of the polyhydroxylated cosolutes (CSLs) methanol (MET), ethylene glycol (ETG), glyc...

CS Pereira，PH Hünenberger - 《Molecular Simulation》

Influence of the Active Pharmaceutical Ingredient Concentration on the Physical State of Mannitol—Implications in Freeze-Drying

The aim of this study was to investigate the effect of the concentration of the active pharmaceutical ingredient on the physical state of mannitol in froze...

X Liao，R Krishnamurthy，R Suryanarayanan - 《Pharmaceutical Research》

The Influence of Intramammary Lipopolysaccharide Infusion on Serum Ca, P, Vitamin D, Cytokines and Cortisol Concentrations in Lactating Sows

Ten multiparous lactating sows were used to investigate whether intramammary infusion of lipopolysaccharides (LPS; Escherichia coli 0111:B4; 2.0 μ g/kg of...

JF Wang，M Wang，JL Ma，... - 《Transboundary & Emerging Diseases》