Composition and method of preparing microparticles of water- insoluble substances
申请(专利)号：
US19970939699
申请日期：
1997-09-29
公开/公告号：
US5922355A
公开/公告日期：
1999-07-13
申请(专利权)人：
RESEARCH TRIANGLE PHARMACEUTICALS
被引量：
摘要：
Submicron size particles of pharmaceutical or other water- insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage.
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