Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents
摘要：
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)<sub>2</sub> (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
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关键词：
ARYLBORONIC ACIDS ARYL CHLORIDES EFFICIENT SYNTHESIS ACTIVE CATALYST ZINC CONVENIENT EXCHANGE BROMIDES CENTERS SYSTEM
DOI：
10.1021/jo8015852
年份：
2008
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