Palladium- and nickel-catalyzed cross-couplings of unsaturated halides bearing relatively acidic protons with organozinc reagents.
摘要：
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
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关键词：
reactions of organo‐metal compounds polyphenyl derivatives polyphenylalkane derivatives alkenes (acyclic compounds) pyridine derivatives amines (benzene compounds) alkynes (benzene compounds)
DOI：
10.1002/chin.200911058
被引量：
年份：
2009
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