METHOD FOR PREPARING DIPHENYLMETHANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
申请(专利)号：
PT19910097768
申请日期：
1991-05-24
公开/公告号：
PT97768A
公开/公告日期：
1992-03-31
申请(专利权)人：
SOCIEDAD ESP. DE ESPEC. FARMACO-TERAPEUTICAS SA.
摘要：
A compound of formula I or a pharmaceutically acceptable salt thereof <CHEM> where -R1 is hydrogen or methyl; -X- is -CO- or -CH2-; -Y- is >CH-A or its vinylogous group >C=CH-CH2-A, wherein -A is a -NR4R5 group, where each R4 and R5, equal or different between them, is C1-C4-alkyl or a phenyl-substituted C1-C4-alkyl; or -A is the N-radical of a 5- or 6-membered, uncharged (i.e. neither quaternary nor zwitterionic) monocyclic ring, either aromatic or non-aromatic, said ring containing one N atom, two N atoms, three N atoms or an N/O pair of atoms, all other atoms in the ring being carbon, and said ring being optionally mono- or di-substituted by groups selected from C1-C4-alkyl, benzyl, 2-furanylmethyl and 2-thienylmethyl; -R2 is hydrogen or a radical C1-C4-alkyl, C1-C4-alkoxy, di-(C1-C4-alkyl)amino, nitro or halogen, said radical being attached at the 2, 3 or 4 substitution positions of the phenyl ring; -R3 is hydrogen, phenyl, C1-C10-alkyl, a C3-C10-alkenyl or alkynyl group with the double or triple bond non-adjacent to the O-C bond, -(CH2CH2O)n-H with n = 1, 2 or 3, -(CHOH)m-H with m = 2, 3 or 4, or -when X is CO-the radical I-bis where Y is defined as above.
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