In addition to the mature 50 amino acid transforming growth factor alpha (TGF alpha), some transformed cells appear to produce multiple higher molecular weight forms. The structure and derivation of most of these larger soluble TGF alpha...
Epidermal growth factor (EGF) and type α transforming growth factor (TGF-α) bind to a specific region in subdomain III of the extracellular portion of th...
We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, an...
Fibroblast to myofibroblast differentiation drives effective wound healing and is largely regulated by the cytokine transforming growth factor-beta 1 (TGF-...
Coexpression of transforming growth factor α (TGF-α) and its receptor epidermal growth factor receptor (EGFR) is known to be associated with aggressive b...
Epidermal growth factor (EGF) and type alpha transforming growth factor (TGF-alpha) bind to a specific region in subdomain III of the extracellular portion...
Binding of human growth hormone (hGH) to its receptor is required for regulation of normal human growth and development. Examination of the 2.8 angstrom cr...
The non-covalent assembly of proteins that fold separately is central to many biological processes, and differs from the permanent macromolecular assembly ...
This chapter discusses the maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement (MIR) and multiwavelength anomalous diff...
Describes three different crystal structures of the extracellular ligand-binding region of mGluR1, a metabotropic glutamate receptor involved in excitatory...
Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide range of physiological and pathological activities. Signal...
The epidermal growth factors (EGFs)are powerful mitogens for a wide variety of cells in culture; human EGF (hEGF), known as urogastrone, also inhibits gast...
The epidermal growth factor receptor plays crucial roles throughout the development of multicellular organisms, and inappropriate activation of the recepto...
Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-尾 (TGF-尾) superfamily of multifunctional cytokines. BMP-2 can induce ec...
The epidermal growth factor receptor plays crucial roles throughout the development of multicellular organisms, and inappropriate activation of the recepto...
The solution structure of the 63-residue heregulin-alpha (HRG-alpha) epidermal growth factor (EGF)-like domain, corresponding to residues 177-239 of HRG-al...
