Apoptosis modulator BCL-B and methods for making and using same
申请(专利)号：
US12426479
申请日期：
20090420
公开/公告号：
US07846681B2
公开/公告日期：
20101207
申请(专利权)人：
John C. Reed Ning Ke Adam Godzik
国省代号：
US,US,US
摘要：
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-2. BCl-XL, and Bax but not Bak. Bcl-B displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family. Accordingly, provided herein is a method for identifying a molecule that binds to the Bcl-B polypeptide, by contacting the Bcl-B polypeptide with a test molecule and determining whether the test molecule binds to the polypeptide.
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