Modified family 6 glycosidases with altered substrate specificity

A modified Family 6 glycosidase enzyme comprising amino acid substitutions at one or more positions selected from the group 182, 367, 399, 400 and 427 is provided (the position determined form alignment of a parental Family 6 glycosidase...

J Tomashek，J Lavigne，A Tremblay，... - EP

Method for designing a drug regime for HIV-infected patients

The instant disclosure describes a novel genotype and phenotype assay to elucidate and/or evaluate new potential HIV integrase inhibitors, but also currently approved and experimental compounds that target protease, reverse transcriptase...

VAN BAELEN, Kurt，STUYVER, Lieven Jozef，ARIËN, Kevin Karel Florentina - WO

PURIFICATION OF SYNTHETIC OLIGOMERS

This invention provides a novel method for purifying synthetic oligomers comprising capping, polymerizing and separating any failure sequences produced during oligomer synthesis. Either the failure sequence or the full-length oligomer ma...

S Fang - US

Herpesvirus ribozymes and vectors

Hammerhead ribozymes that target components critical to HSV replication (ICP4, U L 20, U L 30, and U L 54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several clo...

AS Lewin，DC Bloom，GS Schultz，... - US

METHOD FOR DESIGNING A DRUG REGIME FOR HIV-INFECTED PATIENTS

The instant disclosure describes a novel genotype and phenotype assay to elucidate and/or evaluate new potential HIV integrase inhibitors, but also currently approved and experimental compounds that target protease, reverse transcriptase...

VB Kurt，SL Jozef，AKK Florentina

NUCLEASE-RESISTANT RNA APTAMER INHIBITING REPLICATION OF HEPATITIS C VIRUS REPLICON

Disclosed a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and is composed of at least one ...

Seong-Wook Lee，Kyung-Sook Shin，Jong-Hoon Lim，...

Apoptosis modulator BCL-B and methods for making and using same

A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apo...

JC Reed，K Ning，A Godzik

N-ACETYLHEXOSAMINE SULFUR DERIVATIVES AND USE OF SAME AS CELL TUMOR INHIBITORS

The present invention relates to a series of thioglycosides and to the oxidized sulfoxide and sulfone derivatives thereof, which provide better solubility in aqueous media, and to the use thereof as anti-tumor agents, principally against...

A Fernándezmayoralas，M Nietosampedro，J Casas Brugulat，... - WO

Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools

The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools.

SP Bajpai，SK Srivastav，SC Srivastava