Mechanisms of phagocytosis in macrophages.

Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of...

A Aderem，DM Underhill - 《Annual Review of Immunology》

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES.

Discusses the mechanism of phagocytosis of pathogens in macrophages. Information on phagocytosis; Maturation of the phagosomal vacuole; Major functions of ...

Aderem，Alan，Underhill，... - 《Annual Review of Immunology》

Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K: A lineage of myeloid cells independent of myb and hematopoietic stem cells

Discusses the mechanism of phagocytosis of pathogens in macrophages. Information on phagocytosis; Maturation of the phagosomal vacuole; Major functions of ...

C Schulz，E Gomez Perdiguero，L Chorro，...

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

Alzheimer disease is a progressive dementia with unknown etiology that affects a growing number of the aging population. Increased expression of inflammato...

T Wyss-Coray - 《Nature Medicine》

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

In atherosclerosis and Alzheimer's disease, deposition of the altered self components oxidized low-density lipoprotein (LDL) and amyloid-beta triggers a pr...

CR Stewart，LM Stuart，K Wilkinson，... - 《Nature Immunology》

TREM2 variants in Alzheimer's disease

In atherosclerosis and Alzheimer's disease, deposition of the altered self components oxidized low-density lipoprotein (LDL) and amyloid-beta triggers a pr...

R Heun

TREM2Variants in Alzheimer's disease

BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. METHODS: We used...

Williams，Julie

TREM2 variants and Alzheimer's disease

Evaluation of: Guerreiro R, Wojtas A, Brás Jet al.TREM2variants in Alzheimers disease.N. Engl. J. Med.368(2), 117–127 (2013); Jonsson T, Stefansson H, St...

G Tosto，C Reitz - 《Future Neurology》

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

The introduction of two transgenes into one animal is increasingly common as transgenic experiments become more sophisticated. In this study we examine two...

JL Jankowsky，HH Slunt，T Ratovitski，... - 《Biomolecular Engineering》

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

Microglia are the principal immune cells of the brain. In Alzheimer disease, these brain mononuclear phagocytes are recruited from the blood and accumulate...

J El Khoury，M Toft，SE Hickman，... - 《Nature Medicine》