GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity.

GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas (β-cells) and gastrointestinal tract (enteroendocrine cells) in humans. De-...

HA Overton，MCT Fyfe，C Reynet - 《Br J Pharmacol》

Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Rece...

The molecular mechanism of action of 螖 9 -tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis , has been a puzzle during the three decade...

L De Petrocellis，VD Marzo - 《Journal of Neuroimmune Pharmacology》

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity

GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas (尾-cells) and gastrointestinal tract (enteroendocrine cells) in humans. De-...

HA Overton，MCT Fyfe，C Reynet - 《British Journal of Pharmacology》

NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS

The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of G protein-coupled receptors, particularly...

JB Son，ND Kim，YK Chang，... - US

Trans-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer.

Dietary trans-palmitoleic acid (trans 16:1n-7, tPOA), a biomarker for high-fat dairy product intake, has been associated with a lower risk of type 2 diabetes mellitus (T2DM) in some cross-sectional and prospective epidemiological studies...

E Korkus，M Szustak，R Madaj，... - 《Food & Function》

METHOD FOR MODULATING THE G GPR119 PROTEIN-COUPLED RECEIVER AND SELECTED COMPOUNDS

Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, p...

DA Wacker，KA Rossi，Y Wang

G-protein-coupled receptors function as logic gates for nanoparticle binding using systems and synthetic biology approach

G-protein-coupled receptor 142 (GPR142) belongs to rhodopsin family. GPR142 and GPR119, both G(q)-coupled receptors, are expressed in pancreatic beta cells...

AC Kaushik，X Mao，CD Li，... - 《Journal of Materials Research》

Deciphering G-Protein-Coupled Receptor 119 Agonists as Promising Strategy against Type 2 Diabetes Using Systems Biology Approach

Type 2 diabetes (T2D)has been established as a serious and chronicmedical condition with clinical feature of insulin deficiency andthe resultant pathologic...

AC Kaushik，A Kumar，Rehman, Ashfaq Ur，... - 《Acs Omega》

Method for modulating GPR119 G protein-coupled receptor and selected compounds

Wacker Dean A.Wang YingWACKER D A,ROSSI K A,WANG Y.Method formodulating GPR119 G protein-coupled receptor andselected compounds. WO,2009012277 A1 . 2009WACKER D A,ROSSI K A,WANG Y.Method formodulating GPR119 G protein-coupled ...

KA Rossi，DA Wacker，Y Wang