克里唑替尼合成路线图解
克里唑替尼(crizotinib,1),化学名为3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶基)-1H-吡唑-4-基]-2-氨基吡啶,是由辉瑞公司研发的用于治疗间变性淋巴瘤激酶(A...
孙亚飞,孙占莉,肖旭华 - 《中国医药工业杂志》
Simeprevir的合成路线图解
Simeprevir(TMC-435,1),化学名为(2R,3aR,10Z,11aS,12aR,14aR)-N-(环丙磺酰 基)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-十四氢-2-[[7-甲氧基-8-甲基-2-[4-(1-甲基乙 基)...
安辰红,尚振华,ANChenhong,... - 《中国医药工业杂志》
ANTIBACTERIAL 2H-INDAZOLE DERIVATIVES
The invention relates to antibacterial compounds of formula I wherein R1 is H or halogen; R2 is alkynyloxy or the group M; R3 is H or halogen; M is one of the groups wherein A is a bond, CH2CH2, CH═CH or C≡C and R1A, R2A, R3A, R1B and ...
GAUVIN Jean-Christophe,MIRRE Azely,OCHALA Etienne,...
抗HCV药物TMC-435中间体的合成
丙型肝炎病毒是世界各地出现慢 性肝炎的主要原因,在最初的急性感染之后,大多数受感染的个体会发展成为慢性肝炎.慢性肝炎的发生和感染患者的数量不断增加,这使得HCV的...
安辰红 - 河北科技大学
4-羟基-2-(4-异丙基噻唑-2-基)-7-甲氧基-8-甲基喹啉的合成
2-甲基-3-硝基苯酚经甲基化,傅-克酰化和硝基还原反应得2-甲基-3-氨基-4-乙酰基苯甲醚(2).3-甲基-2-丁酮经溴代,环合,Sandmeyer反应,氰基取代和碱性水解反应得4-异丙基...
安辰红,张赫明,王辉,... - 《中国医药工业杂志》
一种tmc-435重要中间体的制备方法
本发明公开了一种TMC-435重要中间体的制备方法,其步骤为:1,化合物B在碱性条件下与硫酸二甲酯经甲基化反应得化合物C;2,化合物C经付克酰基化反应得化合物D;3,化合物D经铁粉还原为氨基化合物-中间体I;4,化合物E经羰基a-位溴化反应得化合物F;5,化合物F与硫脲环...
尚振华,安辰红
ANTAGONISTS OF GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO
The present invention relates to compounds of Formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are antagonists of GPR119 useful in the treatment of, for example, a disorder selected from: obesity and ...
JONES, Robert M.,TW Schwartz,LV Kristensen,...
Antibacterial benzothiazole derivatives
The invention relates to antibacterial compounds formula (I) wherein R 1 is the group M, whereby M is one of the groups M A and M B represented below wh...
C Schmitt,JP Surivet,G Chapoux,...
COMPOSITIONS COMPRISING STATINS, BIGUANIDES AND FURTHER AGENTS FOR REDUCING CARDIOMETABOLIC RISK
Compositions and methods comprising at least one biguanide compound and at least one statin combined with at least one additional active agent in fixed dose combinations are provided for reducing cardiometabolic risk, and for the treatme...
BARON Alain D.,FINEMAN Mark S.,BEELEY Nigel R. A. - WO