Transdermal therapeutic system with fentanyl or related substances
申请(专利)号：
US201916719086
申请日期：
2019-12-18
公开/公告号：
US10940122B2
公开/公告日期：
2021-03-09
申请(专利权)人：
LTS LOHMANN THERAPIE-SYSTEME AG
国省代号：
DE
被引量：
摘要：
The invention relates to a transdermal therapeutic system (TTS), comprising a backing layer, which is permeable to the active ingredient, at least one matrix layer, comprising fentanyl or an active agent analogous to fentanyl, based on polyacrylate and a protective layer to be removed before usage, characterized in that the polyacrylate polyer is self-adhesive, free of carboxyl groups, has a saturation solubility for fentanyl of 3 to 20 wt. %, preferably of 4 to 12 and particularly of 5 to 10 wt. % and the layers contain at least 80% of the included active ingredient in a molecularly-dispersed, dissolved form.
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