C-aryl glucoside SGLT2 inhibitors and method
A method is provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of a compound of the formula alone or in combination with one or more other antidiabetic agent(s) or other therapeutic agent(s).
WN Washburn，B Ellsworth，M Wei，... - US
Isoxazolyl endothelin antagonists
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-...
N Murugesan，JC Barrish，Z Gu，... - US
Novel thyroid receptor ligands and method
Novel thyroid receptor ligands as provided which have general formula (I) in which: R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or ...
LI YI-LIN，LIU YE，HEDFORS ASA，... - WO
Catecholamine surrogates useful as β3 agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds are beta three adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestina...
PTW Cheng，GS Bisacchi，AV Gavai，... - CA
Antidiabetic 3,4,5-trihydroxypiperidines
The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said compounds and compositions.
B Junge，HP Krause，L Muller，... - US
Thyroid receptor ligands
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or differe...
J Hangeland，Zhang, Minsheng，Y Caringal，... - WO
Phenylderivate as inhibitors of ATP citrate lyase
Compounds of the formula ##STR1## where the substituents are defined in the specification useful in the treatment of hyperlipidemia.
AD Gribble，PHE Groot，AN Shaw，... - US
Naphthalene derivatives
Naphthalene derivatives represented by the formula (I): wherein the symbol represents -X- represnts -O- or -S-, =Y- represents =N- or =CR-, R, C, R, ...
U Hiroaki，O Takayuki，S Ichiro，... - EP
Antilipemic agents; anticancer, antitumor agents
wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which com...
PT Cheng，P Devasthale，Y Jeon，... - US
Anellierte 4-Carboxyamino-2-Methyl-1,2,3,4-Tetrahydrochinoline als CETP-Hemmer
wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which com...
MP Deninno，RB Ruggeri，RT Wester - EP
