THYROID RECEPTOR LIGANDS
New ligands for thyroid receptor provides a kind of compound with general formula (I), in which: n is integer 0 to 4; R1 is halogen, the naphthenic base or 3 to 7 carbon atoms of 1 to 6 carbon atom of trifluoromethyl or alkyl; R2 and R3 ...
HANGELAND Jon，ZHANG Minsheng，CARINGAL Yolanda，... - CA
Melanin concentrating hormone receptor antagonist
Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I
Hulme; Christopher (Indianapolis, IN), Tempest; Paul A. (Somerville, MA), Ma; Vu Van (Simi Valley, C - US
Thyroid receptor ligands
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or differe...
J Hangeland，Zhang, Minsheng，Y Caringal，... - WO
Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formula wherein R 1 , R 2 and R 2a are independently hydrogen, OH, OR 5 , alkyl, —OCHF 2 , —OCF ...
JZ Gougoutas - EP
Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-魏B activity including obesity, diabetes, inflammatory and immune diseases, and have th...
J Duan，Z Lu，DS Weinstein，... - US
Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These com...
BS Company - EP
[6,5]—bicyclic GPR119 G protein-coupled receptor agonists
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, p...
JM Fevig，DA Wacker
BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS
Novel compounds of structure Formula I: or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein A, D, Di, E, J, L, n, Q, Rand Rare defined herein, are provided which are GPR119 G protein- coupled receptor modulators. G...
YE Xiang-Yang，DA Wacker，JA Robl，...
A method for modulating the GPR119 G protein-coupled receptors and selected compounds
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupl...
DA Wacker，K Rossi，Y Wang
Melanin concentrating hormone receptor antagonist
wherein A, W, X, Z, R 1 -R 3 , and R 8 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a s...
C Hulme，PA Tempest，VV Ma，... - US
