Studies on the resistance of desoxyribonucleic acids to physical and chemical factors
摘要：
The human and ox DNA were prepared by methods one of which included the addition of DNA having transforming activity, to serve as a marker of "non-denaturation". The DNAs so prepared were tested for their resistance to heat, ionic strength, dehydration, DNAse, HCHO, H 2O 2, Fe +2, and various other mutagenic or protein denaturing agents. No significant significant species differences in resistance were found. The resistance to heat was found to be considerably higher than in the preparations in which the injurious effects of low ionic strength, dehydration or minute traces of DNAse were not excluded. This loss of stability to heat in specified conditions was found to be a sensitive criterion of injuries to the DNA molecule. The parallel findings of the loss of transforming activity of hemophilus influenzae DNA are compared.
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DOI：
10.1016/0006-3002(54)90362-5
被引量：
年份：
1954
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