The influence of bicarbonate administration on blood pH in a "closed system": Clinical implications
摘要：
An in vitro comparison was made of the effect of isotonic and hypertonic NaHCO 3 solutions on blood pH when the elimination of carbon dioxide was prevented. The results demonstrate that the rise in P co 2 which occurs after addition of isotonic NaHCO 3 offsets the increase in bicarbonate concentration, and the rise in pH is extremely small. The addition of bicarbonate in hypertonic solutions produces a greater elevation of P co 2 and blood pH may actually fall. The acidosis associated with hypertonicity of extracellular fluids results from the dilution of extracellular buffers and the release of protons from intracellular buffers, such as hemoglobin, in response to the increase in ionic strength.
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DOI：
10.1016/S0022-3476(72)80073-8
被引量：
年份：
1972
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