Substrate Stereochemistry of the Enoyl-CoA Hydratase Reaction

1A specimen of stereospecifically 2-tritiated 3-hydroxybutyric acid was prepared by hydroboration of ethyl crotonate. It was assumed that the hydroboration...

P Willadsen，H Eggerer - 《European Journal of Biochemistry》

A novel generation of optically active ethyl 4-chloro-3-hydroxybutyrate as a C4 chiral building unit using microbial dechlorination

A novel procedure for the generation of optically active ethyl 4-chloro-3-hydroxybutyrate using bacterial cells was developed. Ethyl (S)-4-chloro-3-hydroxy...

Toshio，Suzuki，and，... - 《Tetrahedron Asymmetry》

Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine ...

A liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS/MS) method was developed to analyze human urine for 4...

SS Hecht，DK Hatsukami，LE Bonilla，... - 《Chemical Research in Toxicology》

Stereoselectivity of NCS-382 binding to γ-hydroxybutyrate receptor in the rat brain

纬-Hydroxybutyric acid (GHB), a naturally occurring metabolite of 纬-aminobutyric acid (GABA), has been postulated to act both as a specific agonist of GHB...

M.Paola Castelli a，Ignazia Mocci a，Marco Pistis b，... - 《European Journal of Pharmacology》

A two‐step enzymatic resolution process for large‐scale production of (S)‐ and (R)‐ethyl‐3‐hydroxybutyrate

An efficient two-step enzymatic process for production of (R)- and (S)-ethyl-3-hydroxybutyrate (HEB), two important chiral intermediates for the pharmaceut...

A Fishman，M Eroshov，SS Dee‐Noor，... - 《Biotechnology & Bioengineering》

Enzymatic esterification of 3-hydroxybutyric acid

Candida cylindracea lipase catalysed esterification of (±)-3-hydroxybutyric acid (1) with n-butanol was studied in different solvents. This provided an a...

S Chattopadhyay，VR Mamdapur - 《Biotechnology Letters》

Characterisation of a 3-hydroxypropionic acid-inducible system from Pseudomonas putida for orthogonal gene expression control in Escherichia coli and Cupriavidus necator

We investigate the kinetics and dynamics of the PpHpdR/PhpdH switchable system in response to 3-HP and show that it is also induced by both enantiomers of 3-hydroxybutyrate. These findings pave the way for use of the 3-HP-...

EKR Hanko，NP Minton，N Malys - 《Scientific Reports》

A new efficient synthesis of both enantiomers of macrosphelide core: A potential precursor for functionalized macrosphelides

The asymmetric synthesis of a macrosphelide core (1) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compound...

MATSUYA，Yuji，KAWAGUCHI，... - 《Heterocycles》

Two-Dimensional Chiral HPLC Analysis of Lactate, Hydroxybutyrates and Malate in Human Plasma

For the simultaneous determination of lactate (LA), 2-hydroxybutyrate (2HB), 3-hydroxybutyrate (3HB) and malate (MA) enantiomers, a new separation techniqu...

HM Tsai，CL Hsieh，C Ishii，... - 《Chromatography》