Taking Cell-Matrix Adhesions to the Third Dimension
摘要：
Adhesions between fibroblastic cells and extracellular matrix have been studied extensively in vitro, but tittle is known about their in vivo counterparts. Here, we characterized the composition and function of adhesions in three-dimensional (3D) matrices derived from tissues or cell culture. "3D-matrix adhesions" differ from focal and fibrillar adhesions characterized on 2D substrates in their content of alpha (5)beta (1) and alpha (v)beta (3) integrins, paxillin, other cytoskeletal components, and tyrosine phosphorylation of focal adhesion kinase (FAK). Relative to 2D substrates, 3D-matrix interactions also display enhanced cell biological activities and narrowed integrin usage. These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms.
展开
关键词：
Animals Humans Mice Fibroblasts Cells, Cultured 3T3 Cells Focal Adhesions Extracellular Matrix Glutaral Cycloheximide
DOI：
10.1126/science.1064829
被引量：
年份：
2001
万方医学
Semantic Scholar
dx.doi.org
JSTOR
NCBI
查看更多
Cell Press
NCBI
Europe PMC
Oxford Univ Press
AACR
JBC
adsabs.harvard.edu
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
go.galegroup.com
circ.ahajournals.org
SAGE
ar.iiarjournals.org
embor.embopress.org
physiolgenomics.physiology.org
d.scholar.cnki.net
temple.pure.elsevier.com
www.socolar.com
jimmunol.org
science.sciencemag.org
(全网免费下载)
fertstert.org
ganino.com
(全网免费下载)
cshperspectives.cshlp.org
pubfacts.com
jacionline.org
scienceopen.com
mysciencework.com
jleukbio.org
science-open.com
zygx.nwpu.edu.cn
(全网免费下载)
molbiolcell.org
mcb.asm.org
jcs.biologists.org
bloodjournal.org
rstb.royalsocietypublishing.org
onAcademic
fasebj.org
oarsijournal.com
sciencemag.org
jem.rupress.org
biochemj.org
cghjournal.org
mendeley.com
f1000.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
