Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture

When embryonic stem cells are cultured directly in semisolid media (methyl cellulose), they proliferate and differentiate to generate colonies known as emb...

MV Wiles，Keller G.M. - 《Development》

Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.

Hybrid human — mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5′ part of the mouse Thy-1.1 gene combined with the 3′ human untranslated regions was express...

G Kollias，DJ Evans，M Ritter，... - 《Cell》

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

In addition to its role in the recognition of foreign antigens, the T cell receptor (TCR) alpha gene serves as a model system for studies of developmentall...

IC Ho，P Vorhees，N Marin，... - 《Embo Journal》

The erythroid-specific transcription factor eryf1: A new finger protein

The erythroid-specific transcription factor Eryf1 binds to DNA sites within regulatory regions of every member of both the α- and β-globin families in ch...

Todd，Evans，and，... - 《Cell》

Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R.. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87: 27-45

The in vitro developmental potential of mouse blastocyst-derived embryonic stem cell lines has been investigated. From 3 to 8 days of suspension culture the cells form complex embryoid bodies with endoderm, basal lamina, mesoderm and ect...

TC Doetschman，HR Eistetter，M Katz，... - 《Journal of Embryology & Experimental Morphology》

The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop ...

The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans has been sequenced and its transcript mapped and orientated. A si...

B Kudla，MX Caddick，T Langdon，... - 《Embo Journal》

Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages

The nuclear factor GF-1 (also known as NF-E1, Eryf-1; refs 1-3 respectively) is important in regulation of the transcription of globin and other genes that...

DIK Martin，LI Zon，G Mutter，... - 《Nature》

Megakaryocytic and erythrocytic lineages share specific transcription factors

Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1; refs 1-3 respectively), the principal DNA-binding protein of the ery...

PH Romeo，MH Prandini，V Joulin，... - 《Nature》

Expression of GATA-binding proteins during embryonic development in Xenopus laevis

Proteins that recognize the core sequence GATA are important regulators of hematopoietic-specific gene transcription. We have characterized cDNAs encoding ...

Zon, L. I，C Mather，S Burgess，... - 《Proceedings of the National Academy of Sciences of the United States of America》

elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family.

The short, asymmetrical DNA sequence to which the vertebrate GATA family of transcription factors binds is present in some Caenorhabditis elegans gene regu...

J Spieth，YH Shim，K Lea，... - 《Molecular & Cellular Biology》