Process for the organic synthesis of oligosaccharides and derivatives thereof

The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine ...

M Petitou，JC Jacquinet，P Sinay，... - US

Oligosaccharides having selective anticoagulation activity

The invention relates to an oligosaccharide which contains 4-8 monosaccharide units and which is characterized in that it contains at least one glucosamine unit which is 3-0-sulfated, and at least one additional glucosamine unit, whereby...

Baeckstroem, Lindahl Thunberg G. U. J. - US

Method for carrying out the organic synthesis of oligosaccharides containing galactosamine-uronic acid patterns, new oligosaccharides obtained and biological applications thereof

Novel processes for synthesizing acid mucopolysaccharide fragments having from 2-12 saccharides and substantially pure products of a single structure produced thereby. Condensation are disclosed between a first protected saccharide and a...

JC Jacquinet，M Petitou，P Sinay，... - US

Heparin cofactor ii-specific catalytic agent that inactivates clot-bound thrombin

The present invention provides compositions and methods for inactivating thrombin bound to fibrin within a thrombus or clot, whereby the ability of clot-bo...

JI Weitz，J Hirsh，E Young - US

Disaccharides having units with a glucosamine and with a uronic-acid structure, their preparation and their biological application

1,4 alpha disaccharides of formula: with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a functional group such as an acid group, or ...

P Maurice，S Pierre，C Jean，...

METHOD FOR CARRYING OUT THE ORGANIC SYNTHESIS OF OLIGOSACCHARIDES CONTAINING GALACTOSAMINE-URONIC ACID PATTERNS, NEW OLIGOSACCHARIDES OBTAINED AND BIOLOGIC...

Process for the organic synthesis of oligosaccharides forming or corresponding to fragments of acid mucopolysaccharides wherein two compounds comprised of ...

JC Jacquinet，M Petitou，P Sinay，...

Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics

The present invention generally relates to a processes for preparing low affinity, low molecular weight heparins (LA-LWM-heparins) which are endowed with pharmacological and therapeutic properties that are surprisingly advantageous. In o...

J Hirsh，PN Shaklee，JE Knobloch，... - US

Mixture of heparin cofactor, antithrombin and water; anticoagulants

The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to m...

J Hirsh，JI Weitz - WO

Compositions and methods for inhibiting thrombogenesis

The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, inter alia, is capabl...

J Hirsh，JI Weitz - WO

ONTAINING GALACTOSAMINE-URONIC ACID PATTERNS, NEW OLIGOSACCHARIDES OBTAINED AND BIOLOGICAL APPLICATIONS THEREOF METHOD FOR ORGANIC SYNTHESIS OF OLIGOSACCHARIDES C

the invention relates to a station for the purification of water holding of the type operating according to a process anaerobic. This station comprises a sealed vessel 1, at least one of the separation of the inner partition 3, dividing ...

J Jean-Claude，P Maurice，S Pierre，...