Transthyretin sequesters amyloid beta protein and prevents amyloid formation
摘要：
The cardinal pathological features of Alzheimer disease are depositions of aggregated amyloid β protein (Aβ) in the brain and cerebrovasculature. However, the Aβ is found in a soluble form in cerebrospinal fluid in healthy individuals and patients with Alzheimer disease. We postulate that sequestration of Aβ precludes amyloid formation. Failure to sequester Aβ in Alzheimer disease may result in amyloidosis. When we added Aβ to cerebrospinal fluid of patients and controls it was rapidly sequestered into stable complexes with transthyretin. Complexes with apolipoprotein E, which has been shown to bind Aβ in vitro, were not observed in cerebrospinal fluid. Additional in vitro studies showed that both purified transthyretin and apolipoprotein E prevent amyloid formation.
展开
DOI：
doi:10.1073/pnas.91.18.8368
被引量：
年份：
1994
BMJ
万方
Semantic Scholar
dx.doi.org
Europe PMC
(全网免费下载)
查看更多
NCBI
Europe PMC
JSTOR
JBC
adsabs.harvard.edu
ResearchGate
(全网免费下载)
ResearchGate
钛学术
(全网免费下载)
mendeley.com
学术范
(全网免费下载)
jlr.org
pnas.org
(全网免费下载)
学术范
mysciencework.com
jn.nutrition.org
pure.au.dk
jneurosci.org
pnas.org
atvb.ahajournals.org
deepdyve.com
core.ac.uk
forskningsdatabasen.dk
钛学术
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
