Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
A stabilized conjugated peptide complex comprising a peptide conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the peptide may for example be selected from the group consisting of insulin, calciton...
NN Ekwuribe
Method and composition for the treatment of diabetes
This invention is directed to a novel method and composition for the treatment of diabetes mellitus (Type I, Impaired Glucose Tolerance [“IGT”] and Type II). More specifically, this invention pertains to a novel met...
RB Rieveley - US
Enkephalin conjugates
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier ("BBB") and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeuti...
NN Ekwuribe，B Rhadakrishnan，CH Price，... - US
Aerosol formulations of peptides and proteins
A pharmaceutical aerosol formulation comprising (a) a HFA propellant; (b) a pharmaceutically active polypeptide dispersible in the propellant; and (c) a surfactant which is a C-Cfatty acid or salt thereof, a bile salt, a phospholipid, or...
Bäckström,Kjell，Dahlbäck,Magnus，A Johansson，... - EP
Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
A stabilized conjugated therapeutic agent complex comprising a therapeutic agent conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the therapeutic agent may for example be selected from the group c...
NN Ekwuribe - US
Amphiphilic drug-oligomer conjugates with hydrolyzable lipophile components and methods for making and using the same
The invention provides a drug-oligomer conjugate having the following general formula:wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branche...
NNOCHIRI EKWURIBE，MUTHUKUMAR RAMASWAMY，JAYANTHI RAJAGOPALAN - US
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a poly...
NN Ekwuribe - US
Pellets containing peptide drugs, their manufacture and use
Described are pellets containing peptide drugs incorporated in a matrix consisting of gelatin or fractionated gelatin and plasticizers, the pellets having a semi-solid to gel-like consistency. Such drug forms exhibit, after application, ...
JC Wunderlich，U Schick，J Werry，... - WO
Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
A therapeutic formulation comprising a microemulsion of a therapeutic agent in free and/or conjugatively coupled form, wherein the microemulsion comprises a water-in-oil (w/o) microemulsion including a lipophilic phase and a hydrophilic ...
NN Ekwuribe，M Ramaswamy，B Radhakrishnan，... - US
Nasal formulation and intranasal administration therewith
The systemic absorption after intranasal administration of certain drugs, in particular pharmacologically active polypeptides is enhanced in the presence of a phospholipid, such as a phosphatidylcholine (a lecithin) , preferably admixed ...
PE Hansen，AR Sorensen - US
