The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of p...
The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of p...
GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by mechanisms that are not completely understood. Fusion between early endosomes requires phosphatidylinositol-3-OH kinase (PI(3)K) activity as well as the s...
Recent crystallographic analyses of membrane-tethering FYVE finger domains from proteins involved in the regulation of endocytic vesicle trafficking have l...
Analyzes the lipid interactions of the FYVE protein domain using the nuclear magnetic resonance (NMR) spectroscopy. Properties of phosphatidylinositol; Cry...
Analyzes the lipid interactions of the FYVE protein domain using the nuclear magnetic resonance (NMR) spectroscopy. Properties of phosphatidylinositol; Cry...
The FYVE finger domain was demonstrated to bind to phosphatidylinositol-3-phosphate (PtdIns(3)P). Data obtained provided in vivo evidence that the FYVE fin...
but requires an additional membrane-insertion and/or oligomerization component in the case of the PtdIns(3)P-targeting phox homology (PX) and FYVE domains...
Vac1p contains a zinc-binding FYVE finger that may bind phosphatidylinositol 3-phosphate [PtdIns(3)P]. In other FYVE domain proteins, this motif and ...
Phosphatidylinositol 3-kinase (PI3K) regulates several vital cellular processes, including signal transduction and membrane trafficking. In order to study ...
The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of p...
Top of pageREGULATION OF SMAD ACTIVATION TRANSCRIPTIONAL CONTROL BY SMADs NEGATIVE REGULATION OF R- AND CO-SMADs SMAD FUNCTION IN TGF-β-INDUCED RESPONSES ...
SNAREs and Rab GTPases cooperate in vesicle transport through a mechanism yet poorly understood. We now demonstrate that the Rab5 effectors EEA1 and Rabapt...
Down-regulation (degradation) of cell surface proteins within the lysosomal lumen depends on the function of the multivesicular body (MVB) sorting pathway....
Little is known about the dynamics and molecular components of plant prevacuolar compartments (PVCs). We have demonstrated recently that vacuolar sorting r...
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagoso...
Very limited information is available on the role of phosphatidylinositol 3-phosphate (PI[3]P) in vesicle trafficking in plant cells. To investigate the ro...
Focuses on a study of the Rab5 effectors and Rabex-5 existing on the membrane in high molecular oligomers. Interaction between EEA1 and Syntaxin 13 require...
