FYVE fingers bind PtdIns(3)P
摘要：
The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of phosphatidylinositol by phosphatidylinositol-3-OH kinase (PI(3)K). PtdIns(3)P is important for vesicular transport, but little is known about how it acts, and proteins that specifically recognize it have not yet been identified. Here we identify the FYVE finger, an evolutionarily conserved double-zinc-binding domain (see Supplementary information), as a protein structure that binds to PtdIns(3)P with high specificity.
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关键词：
Cell Line Animals Humans GTP-Binding Proteins rab5 GTP-Binding Proteins Phosphatidylinositol Phosphates Membrane Proteins Vesicular Transport Proteins Phosphoproteins Recombinant Fusion Proteins
DOI：
10.1038/28767
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