Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects.
阅读量：
82
摘要：
Resistin is a novel adipocyte-secreted hormone proposed to link obesity with diabetes. Studies in mice have revealed conflicting data however, and the physiological role of circulating resistin in humans remains unknown. We conducted cross-sectional studies in 123 middle-aged women and 120 healthy young subjects and found that serum resistin levels did not correlate with markers of adiposity, including body mass index, waist-to-hip ratio, or fat mass, or insulin resistance assessed by homeostasis model, lipid profile, or serum leptin levels; but females had higher resistin levels than males (P < 0.02). We also found no difference in serum resistin levels between lean healthy and obese insulin-resistant nondiabetic and type 2 diabetic adolescents. Finally, to evaluate the effect of food deprivation and/or leptin administration on resistin levels, we performed interventional studies that revealed no significant difference in resistin levels after 48 h of fasting and/or leptin administration at either physiological or pharmacological doses. We conclude that circulating resistin is unlikely to play a major role in insulin resistance or energy homeostasis in humans.
展开
关键词：
Humans Diabetes Mellitus, Type 2 Insulin Resistance Obesity Hormones, Ectopic Leptin Intercellular Signaling Peptides and Proteins Body Mass Index Fasting Cross-Sectional Studies
DOI：
10.1210/jc.2003-030519
被引量：
年份：
2003
BMJ
academic.oup.com
万方医学
Semantic Scholar
(全网免费下载)
Oxford Univ Press
查看更多
Europe PMC
NCBI
NRC Research Press
ResearchGate
(全网免费下载)
ResearchGate
Citeseer
(全网免费下载)
bioquest.org
(全网免费下载)
jcem.endojournals.org
(全网免费下载)
reproduction-online.org
scienceopen.com
jme.endocrinology-journals.org
mtpstudio.com
(全网免费下载)
eje-online.org
deepdyve.com
ajcn.nutrition.org
bases.bireme.br
bioquest.org
(全网免费下载)
ajpendo.physiology.org
jcem.endojournals.org
diabetes.diabetesjournals.org
uncch.pure.elsevier.com
cghjournal.org
onAcademic
d.scholar.cnki.net
scindeks.ceon.rs
press.endocrine.org
press.endocrine.org
(全网免费下载)
SAGE
stroke.ahajournals.org
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
mtpstudio.com
(全网免费下载)
bioquest.org
(全网免费下载)
jcem.endojournals.org
(全网免费下载)
bioquest.org
(全网免费下载)
press.endocrine.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
