Central nervous system depressant action of flavonoid glycosides
摘要：
The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the glycosides 2 S-hesperidin and linarin, recently isolated from valeriana. The glycosides 2 S-neohesperidin, 2 S-naringin, diosmin, gossipyn and rutin exerted a depressant action on the CNS of mice following i.p. injection, similar to that found with 2 S-hesperidin and linarin. We demonstrate in this work that these behavioural actions, as measured in the hole board, thiopental induced sleeping time and locomotor activity tests, are unlikely to involve a direct action on γ-aminobutyric acid type A (GABA A) receptors. The corresponding aglycones were inactive, pointing to the importance of the sugar moieties in the glycosides in their CNS depressant action following systemic administration. The pharmacological properties of the flavonoid glycosides studied here, in addition to our previous results with hesperidin and linarin, opens a promising new avenue of research in the field.
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DOI：
10.1016/j.ejphar.2006.04.004
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年份：
2006
Elsevier
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掌桥科研
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