TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS
The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a proc...
DOMINIQUE SWINNEN，C Jorand-Lebrun，T Grippi-Vallotton，... - WO
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R 1 , and R 2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmac...
CHARRIER, Jean-Damien，YOUNG, Stephen, Clinton，DAVIS, Christopher, John，... - EP
Pim激酶抑制剂及其制备方法与在制药中的应用
本发明提供了一种式(I)所示的PIM激酶抑制剂,其中E,J,Q,X,Y,Z,m如权利要求1所定义.本发明的PIM激酶抑制剂用于制备治疗或预防癌症,自身免疫性疾病,过敏性反应疾病,动脉...
Yu Ge，葛羽
3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
The present invention relates to the Janus kinase (JAK) inhibitors 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octanenitrile or 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]heptanenitrile, as well as its compositions...
YL Li，JD Rodgers - US
COMPOSITIONS AND METHODS OF OBTAINING AND USING ENDODERM AND HEPATOCYTE CELLS
The invention provides for efficient methods for generating populations of endoderm cells and/or differentiated cells derived from endoderm cells (e.g., hepatic cells, pancreatic precursor cells, pancreatic cells, intestinal progenitor c...
DOUDEMENT Estelle，UPPAL Hirdesh - WO
Kinase inhibitors and methods of their use
The invention provides for efficient methods for generating populations of endoderm cells and/or differentiated cells derived from endoderm cells (e.g., hepatic cells, pancreatic precursor cells, pancreatic cells, intestinal progenitor c...
- US
Pyridyl derivatives, their preparation and use
The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1α (HIF-1α) mediated signaling. Also disclosed are pr...
S Kumar，KS Joshi，V Deore，... - US
HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS
The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activi...
Rodgers, James D，S Shepard，Maduskuie Jr., Thomas P，...
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I
Rodgers, James D，S Shepard，Arvanitis, Argyrios G，... - US
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts ...
X Wang
