Design and synthesis of influenza virus sialidase inhibitors: novel anti-influenza drugs
摘要：
A review with 19 refs. The design and synthesis of carbohydrate-based drugs for the potential treatment and/or prevention of influenza has been accomplished. These compds., N-acetylneuraminic acid derivs., have been designed using an X-ray crystal structure of influenza virus sialidase. The design and synthesis of these compds. is discussed, with particular emphasis on the hitherto unknown thioisosteres of some of the most potent influenza virus sialidase inhibitors. [on SciFinder(R)]
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