A Secondary Amine Amide Organocatalyst for the Asymmetric Nitroaldol Reaction of α-Ketophosphonates
摘要：
Mild conditions: A secondary amine–amide organocatalyst 1 has been applied in the asymmetric Henry reaction of -ketophosphonates. A series of aromatic, heteroaromatic, and aliphatic -ketophosphonates can be converted into the desired -hydroxy-β-nitrophosphonates in moderate to high yields with excellent enantioselectivities (up to 99% ee) under mild conditions. The mechanism of reaction was investigated by theoretical calculations.
展开
关键词：
organo‐phosphorus compounds diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism organocatalysis nitro compounds (benzene compounds
DOI：
10.1002/chem.200801958
被引量：
年份：
2008
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
