Enantioselective Reduction of ,β-Unsaturated Carboxylates with NaBH4 and Catalytic Amounts of Chiral Cobalt Semicorrin Complexes
摘要:
High enantioselectivities (up to 96% ee), almost quantitative chemical yields, and mild reaction conditions characterize the title reaction. It is suitable, for example, for the synthesis of isoprenoid chains as occur in the vitamins E and K1. An example is reaction (a), R CH2OSiMe2tBu.
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DOI:
10.1002/anie.198900601
被引量:
年份:
1989
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