The Enamine Alkylation and Acylation of Carbonyl Compounds

The enamine alkylation and acylation of carbonyl compounds is discussed with regard to the preparation of enamines, their alkylation with electrophilic olefins, their alkylation with alkyl halides and finally their acylation with acid ch...

G Stork，AH Brizzolara，HK Landesman，... - 《Journal of the American Chemical Society》

A review of annulation

INTRODULTION AnnulationS, derived from the Latin work annulatus (ringed) means "the formation of rings".'In organic chemistry this term is used to describe the process of building a ring onto a preexisting system. cyclic or non-cyclic. T...

ME Jung - 《Tetrahedron》

Diterpenoid total synthesis, an A .fwdarw. B .fwdarw. C approach. 12. Aromatic C rings without alkyl substituents. Model systems for podocarpic acid and di...

Examination of the general sequence 2 → 7 for addition of a 13-unsubstituted phenolic C ring2 to decalones 2a-e is described. Condensation of the decalone...

Walter，L.，Meyer，... - 《Journal of Organic Chemistry》

ChemInform Abstract: ALPHA‐SILYLATED VINYL KETONES, A NEW CLASS OF REAGENTS FOR THE ANNELATION OF KETONES

Das Grignard-Reagenz (I) liefert mit den Aldehyden (II) die Alkohole (III), deren Oxidation mit Jones-Reagenz die Enone (IV) ergibt.

G Stork，B Ganem - 《Chemischer Informationsdienst》

Alkylation and Carbonation of Ketones by Trapping the Enolates from the Reduction of ??,??-Unsaturated Ketones

Evidence is given that during the course of the reduction of α,β-unsaturated ketones with lithium in liquid ammonia the β-carbon atom becomes nucleophilic and can be alkylated by a suitably placed electrophilic center. In the more usu...

G Stork，P Rosen，NL Goldman，... - 《Journal of the American Chemical Society》

Haloketal cyclization. General method for the synthesis of functionalized cis bicyclic ketones

Conjugate additions to 3-alkyl-2-methyl-1-acetylcyclopentenes via diethyl aluminum cyanide and via lithium divinylcuprate lead with good or essentially complete stereoselectivity, respectively, to cis 2-cyano-3-alkyl- and trans 2-vinyl-3...

G Stork，JO Gardner，RK Beckman，... - 《Journal of the American Chemical Society》

Mechanism and stereochemical control in the .alpha.-haloketal cyclization. Remarkable effect of metal cations

A one-pot two-step phosphorylation procedure is described which is suitable for the preparation of thermally lacible or highly substituted dialkyl phosphonates for use in Horner-Emmons olefinations. Such systems are not readily available...

G Stork，RK Boeckman - 《Journal of the American Chemical Society》

Carboxylation of ketones using triethylamine and magnesium halides

This chapter contains sections titled

RE Tirpak，RS Olsen，MW Rathke - 《Journal of Organic Chemistry》

Catalyst Selectivity in the Reactions of Unsymmetrical Ketones; Reaction of Butanone with Benzaldehyde and p-Nitrobenzaldehyde

The hydroxy ketone intermediates III and IV from the reaction between benzaldehyde and butanone have been prepared by the Schpf method. Treatment of either the straight-chain isomer III or the branched isomer IV with dilute alkali produc...

M Stiles，D Wolf，GV Hudson - 《Journal of the American Chemical Society》

Rearrangement of Alkyl Groups. Kinetic and Tracer Studies in the Pinacol Rearrangement1

The rearrangement of 2,3-dimethyl-2,3-pentanediol (IIb) in aqueous sulfuric acid yielded 83% methyl t-amyl ketone and 17% ethyl t-butyl ketone. Isotopic labeling showed that the methyl ketone arose both by ethyl migration (69%) and methy...

M Stiles，RP Mayer - 《Journal of the American Chemical Society》