Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
摘要：
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5′ noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.
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关键词：
Cell Line Chromosomes, Human, Pair 3 Humans Translocation, Genetic DNA-Binding Proteins Proto-Oncogene Proteins Transcription Factors DNA, Complementary Gene Rearrangement Amino Acid Sequence
DOI：
10.1126/science.8235596
被引量：
年份：
1993
Elsevier
万方医学
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