Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome

Highly pathogenic avian influenza A viruses of subtypes H5 and H7 are the causative agents of fowl plague in poultry. Influenza A viruses of subtype H5N1 a...

RAM Fouchier，PM Schneeberger，FW Rozendaal，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Rational design of potent sialidase-based inhibitors of influenza virus replication

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of ...

M Von Itzstein，WY Wu，GB Kok，... - 《Nature》

Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus

In May, 1997, a 3-year-old boy in Hong Kong was admitted to the hospital and subsequently died from influenza pneumonia, acute respiratory distress syndrom...

Dr Eric CJ Claas PhD a，Prof Albert DME Osterhaus DVM a，Ruud van Beek MS a，... - 《Lancet》

Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus

Background. Human infection with an avian influenza A virus (subtype H5N1) was reported recently in Hong Kong. We describe the clinical presentation of the...

K Yuen，P Chan，M Peiris，... - 《Lancet》

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groo...

C Lin，SN Willis，A Wei，... - 《Molecular Cell》

Structure of the catalytic and antigenic sites in influenza virus neuraminidase

The catalytic sites of influenza virus neuraminidase are located on the upper corners of the box-shaped tetramer that forms the head of the molecule. Antig...

PM Colman，JN Varghese，WG Laver - 《Nature》

Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing

Neisseria meningitidis is a major cause of bacterial septicemia and meningitis. Sequence variation of surface-exposed proteins and cross-reactivity of the ...

Pizza，M. - 《Science》

Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses.

The gene pool of influenza A viruses in aquatic birds provides all of the genetic diversity required for human and lower animals. Host range selection of t...

Suzuki，Yasuo - 《Biological & Pharmaceutical Bulletin》

Are we ready for pandemic influenza?

During the past year, the public has become keenly aware of the threat of emerging infectious diseases with the global spread of severe acute respiratory s...

Webby，J R. - 《Science》

Human infection with influenza H9N2.

We report the clinical features of two cases of human infection with influenza A virus subtype H9N2 in Hong Kong, and show that serum samples from blood do...

M Peiris，KY Yuen，CW Leung，... - 《Lancet》