Surface antigen expression in spleen cells of C57Bl/6 mice during ageing: influence of sex and parity
摘要：
So far all studies on the murine ageing process have been conducted on virgin mice. Immune ageing may be influenced by sex hormone differences related to sex or pregnancies. The aim of this study was to investigate whether pregnancies and gender influence the cell changes observed during ageing in a peripheral lymphoid compartment of C57Bl/6 mice. Using flow cytometry, changes in (Thy1.2+) T cell, (B220+) B cell and (CD11b/Mac-1) macrophage spleen populations were monitored in 2, 8 (3 months after last pregnancy) 15 and 23-month-old mice including males, virgin and multiparous females. The development of naive (CDCD44low), memory (CD44high), activated/memory (MEL-14, CD62L) cells were investigated in CD4+ and CE8+ T cell subsets. Both short term (at 8 months) and long term (at 15 and 23 months) effects of multiparity were obvious in the lymphocyte/macrophage population changes associated with the ageing process. Short-te
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DOI：
10.1046/j.1365-2249.1997.3021199.x
被引量：
年份：
1997
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